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St. John’s wort

**(Hypericum perforatum)**

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	Bergmann R, Nüssner J, Demling J. The treatment of mild to moderate depression: Hypericum perforatum in comparison with amitriptyline. Neurologie/Psychatiatrie 1993; 4(7): 235-240.
	Bhattacharya SK, Chakrabarti A, Chatterjee SS. Activity profiles of two hyperforin-containing Hypericum extracts in behavioral models. Pharmacopsychiat 1998; 31 (suppl): 22-29.
	Bladt S, Wagner H. Inhibition of MAO by fractions and constituents of Hypericum extract. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S57-S59.
	Butterweck V, Wall A, Liefländer-Wulf U, et al. Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiat 1997; 30(suppl 1): 117-124.
	Chatterjee SS, Bhattacharya SK, Wonnemann M, et al. Hyperforin as a possible antidepressant component of Hypericum extracts. Life Sciences 1998; 63(6): 499-510.
	Chatterjee SS, Nöldner M, Koch E, et al. Antidepressant activity of Hypericum perforatum and hyperforin: the neglected possibility. Pharmacopsychiatry 1998; 31 (suppl): 7-15.
	Ernst E. St. John’s wort, an antidepressant? A systematic, criteria-based review. Phytomedicine 1995; 2(1): 67-71.
	Ernst E. Complementary therapies for depression: an overview. Arch Gen Psychiatry 1998; 55: 1026-1032.
	Gruenwald J. Standardized St. John’s wort extract clinical monograph. Quarterly Review of Natural Medicine Winter 1997: 289-299.
	Gulick RM, McAuliffe V, Holden-Wiltse J, et al. Phase I studies of hypericin, the active compound in St. John’s wort, as an antiretroviral agent in HIV-infected adults. Annals of Internal Medicine 1999; 130(6): 510-514.
	Hänsgen K-D, Vesper J, Ploch M. Multicenter double-blind study examining the antidepressant effectiveness of the Hypericum extract LI 160. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S15-S18.
	Harrer G, Sommer H. Treatment of mild/moderate depressions with Hypericum. Phytomedicine 1994; 1: 3-8.
	Harrer G, Hübner W-D, Podzuweit H. Effectiveness and tolerance of the Hypericum extract LI 160 compared to maprotiline: a multicenter double-blind study. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S24-S28.
	Hübner W-D, Lande S, Podzuweit H. Hypericum treatment of mild depressions with somatic symptoms. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S12-S14.
	Johnson D, Ksciuk H, Woelk H, et al. Effects of Hypericum extract LI 160 compared with maprotiline on resting EEG and evoked potentials in 24 volunteers. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S44-S46.
	Laakmann G, Schüle C, Baghai T, et al. St. John’s wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiat 1998; 31(suppl): S54-S59.
	Lieberman S. Treating depression with St. John's wort: a review of clinical trials. Alternative and Complementary Therapies June 1998; 163-168.
	Linde K, Ramirez G, Mulrow CD, et al. St. John's wort for depression – an overview and meta-analysis of randomized clinical trials. British Medical Journal 1996; 313: 253-258.
	Martinez B, Kasper S, Ruhrmann S, et al. Hypericum in the treatment of seasonal affective disorders. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S29-S33.
	Müller WEG, Rossol R. Effects of Hypericum extract on the expression of serotonin receptors. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S63-S64.Müller WE, Singer A, Wonnemann M, et al. Hyperforin represents the neurotransmitter reuptake inhibiting constituent of Hypericum extract. Pharmacopsychiat 1998; 31(suppl): 16-21.
	Schulz J, Jobert M. Effects of Hypericum extract on the sleep EEG in older volunteers. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S39-S43.
	Schulz H, Jobert M, Hübner WD. The quantitative EEG as a screening instrument to identify sedative effects of single doses of plant extracts in comparison with diazepam. Phytomedicine 1998; 5(6): 449-458.
	Sommer H, Harrer G. Placebo-controlled double-blind study examining the effectiveness of an Hypericum preparation in 105 mildly depressed patients. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S9-S11.
	Stevinson C, Dixon M, Ernst E. Hypericum for fatigue -- a pilot study. Phytomedicine 1998; 5(6): 443-447.
	Thiede H-M, Walper A. Inhibition of MAO and COMT by Hypericum extracts and hypericin. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S54-S56.
	Vitiello B. Hypericum perforatum extracts as potential antidepressants. J Pharm Pharmacol 1998; 50(suppl): 22.
	Volz H-P. Controlled clinical trials of Hypericum extracts in depressed patients -- an overview. Pharmcopsychiatry 1997; 30(suppl): 72-76.
	Vorbach EU, Arnoldt KH, Hübner W-D. Efficacy and tolerability of St. John's wort extract LI160 versus imipramine in patients with severe depressive episodes according to ICD-10. Pharmacopsychiat 1997; 30(suppl): 81-85.
	Vorbach EU, Hübner W-D, Arnoldt K-H. Effectiveness and tolerance of the Hypericum extract LI 160 in comparison with imipramine: randomized double-blind study with 135 outpatients. Journal of Geriatric Psychiatry and Neurology 1994; 7(suppl 1): S19-S23.
	Wheatley D. LI160, an extract of St. John's wort, versus amitriptyline in mildly to moderately depressed outpatients – a controlled 6-week trial. Pharmacopsychiat 1997; 30(suppl): 77-80.
	Woelk H, Burkard G, Grünwald J. Benefits and risks of the Hypericum extract LI160: drug monitoring study with 3250 patients. Journal of Geriatric Psychiatry and Neurology 1993; 7(suppl 1): S34-S38.