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Soy

**(Glycine max)**

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	Adlercreutz H, Markkanen H, Watanabe S. Plasma concentrations of phyto-oestrogens in Japanese men. The Lancet 1993; 342: 1209-1210.
	Akiyama T, Ishida J, Nakagawa S, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. Journal of Biological Chemistry 1987; 262(12): 5592-5595.
	Albertazzi P, Pansini F, Bonaccorsi G, et al. The effect of dietary soy supplementation on hot flushes. Obstetrics and Gynecology 1998; 91(1):6-11.
	Albrecht F. Soy isoflavones: continuing education module. Nutrition Science News 1999; 4(4): 2-6.
	Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. The New England Journal of Medicine 1995; 333: 276-282.
	Arjmandi BH, Alekel L, Hollis BW, et al. Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. Journal of Nutrition 1996; 126: 161-167.
	Arjmandi BH, Getlinger MJ, Goyal NV, et al. Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. American Journal of Clinical Nutrition 1998; 68(suppl): 1358-1363.
	Barnes S. Evolution of the health benefits of soy isoflavones. Proceedings of the Society for Experimental Biology and Medicine 1998; 217(3): 386-392.
	Bland JS. Diet and prostate problems. Alternative Therapies 1995; 1(4): 75-76.
	Carroll KK, Kurowska EM. Soy consumption and cholesterol reduction: review of animal and human studies. Journal of Nutrition (suppl.) 1995; 125: 594S-597S.
	Cassidy A, Bingham S, Setchell KDR. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. American Journal of Clinical Nutrition 1994; 60: 333-340.
	Cassidy A, Bingham S, Setchell K. Biological effects of isoflavones in young women: importance of the chemical composition of soyabean products. British Journal of Nutrition 1995; 74: 587-601.
	Clarkson TB, Anthony MS, Williams JK, et al. The potential of soybean phytoestrogens for postmenopausal hormone replacement therapy. Proceedings of the Society for Experimental Biology and Medicine 1998; 217(3): 365-368.
	Constantinou A, Mehta R, Runyan C, et al. Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships. Journal of Natural Products 1995; 58(2): 217-225.
	Coward L, Barnes NC, Setchell KDR, et al. Genistein, daidzein, and their ß-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 1993; 41: 1961-1967.
	Davis JC. Are biotech foods really safe? Delicious! February 1997: 78-80.
	Fallon SW, Enig MG. How safe is soy? New Life May 1996: 35-39.
	Fanti P, Paugere MC, Gang Z, et al. Systemic administration of genistein partially prevents bone loss in ovariectomized rats via a non-estrogenic-like mechanism. Second International Symposium on the Role of Soy in Preventing and Treating Chronic Disease (Brussels, Belgium), 1996.
	Federal Register. Food Labeling Health Claims: Soy Protein and Coronary Heart Disease (Docket No. 98P-0683). November 10, 1998; 63(217): 62977-63015.
	Fotsis T, Pepper M, Adlercreutz H, et al. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc Natl Acad Sci 1993; 90: 2690-2694.
	Friedrich J. Protective and regulatory benefits of soy: clinical perspectives. Alternative and Complementary Therapies February 1997: 53-58.
	Graf E, Eaton JW. Suppression of colonic cancer by dietary phytic acid. Nutrition and Cancer 1993; 19(1): 11-19.
	Hawrylewicz EJ, Zapata JJ, Blair WH. Soy and experimental cancer: animal studies. Journal of Nutrition 1995; 125: 698S-708S.
	Holt S. Prostatic health: part 1, the optimal diet. Alternative and Complementary Therapies September/October 1996; 302-305.
	Ingram D, Sanders K, Kolybaba M, et al. Case-control study of phyto-oestrogens and breast cancer. The Lancet 1997; 350: 990-994.
	Kennedy AR. The evidence for soybean products as cancer preventive agents. J Nutr 1995 (suppl); 125: 733-743S.
	Knight DC, Eden JA. A review of the clinical effects of phytoestrogens. Obstet Gynecol 1996; 87(5): 897-904.
	Koratkar R, Rao AV. Effect of soya bean saponins on azoxymethane-induced preneoplastic lesions in the colon of mice. Nutrition and Cancer 1997; 27(2): 206-209.
	Lamartiniere CA, Murrill WB, Manzolillo PA, et al. Genistein alters the ontogeny of mammary gland development and protects against chemically-induced mammary cancer in rats. Proceedings of the Society for Experimental Biology and Medicine 1998; 217(3): 358-364.
	Lampe JW, Karr SC, Hutchins AM, et al. Urinary equol excretion with a soy challenge: influence of habitual diet. Proceedings of the Society for Experimental Biology and Medicine 1998; 217(3): 335-339.
	Li W, Weber G. Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells. Life Sciences 1998; 63(22): 1975-1981.
	Liener IE. Possible adverse effects of soybean anticarcinogens. J Nutr 1995; 125: 744S-750S.
	Lo GS, Goldberg AP, Lim A, et al. Soy fiber improves lipid and carbohydrate metabolism in primary hyperlipidemic subjects. Atherosclerosis 1986; 62: 239-248.
	Lovati MR, Allievi L, Sirtori CR. Accelerated early catabolism of very low density lipoproteins in rats after dietary soy proteins (letter to the editor). Atherosclerosis 1985; 56: 243-246.
	Messina M. Modern applications for an ancient bean: soybeans and the prevention and treatment of chronic disease. J Nutr 1995; 125: 567S-569S.
	Molteni A, Brizio-Molteni L, Persky V. In vitro hormonal effects of soybean isoflavones. J Nutr 1995; 125: 751S-756S.
	Monti E, Sinha BK. Antiproliferative effect of genistein and adriamycin against estrogen-dependent and -independent human breast carcinoma cell lines. Anticancer Research 1994; 14: 1221-1226.
	Nakashima S, Koike T, Nozawa Y. Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses. Molecular Pharmacology 1991; 39: 475-480.
	Peterson G, Barnes S. Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene. Biochemical and Biophysical Research Communications 1991; 179(1): 661-667.
	Potter SM. Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J Nutr 1995; 125: 606S-611S.
	Sargeant P, Farndale RW, Sage SO. The tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and genistein reduce thrombin-evoked tyrosine phosphorylation and Ca2+ entry in human platelets. Federation of European Biochemical Societies 1993; 315(3): 242-246.
	Sargeant P, Farndale RW, Sage SO. ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. Journal of Biological Chemistry 1993; 268(24): 18151-18156.
	Tham DM, Gardner CD, Haskell WL. Clinical review 1997: potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. Journal of Clinical Endocrinology and Metabolism 1998; 83: 2223-2235.
	Wei H. Isoflavones scavenge reactive oxygen species and protect DNA bases from oxidative DNA damage. Proceedings of the American Association for Cancer Research March 1994; 35: 16 (poster only).
	Yan C, Han R. Genistein suppresses adhesion-induced protein tyrosine phosphorylation and invasion of B16-BL6 melanoma cells. Cancer Letters 1998; 129: 117-124.
	Zava DT, Duwe G. Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutrition and Cancer 1997; 27(1): 31-40.
	Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proceedings of the Society for Experimental Biology and Medicine 1998; 217(3): 369-378.