Estrogenic compounds in parsley isolated
In the process of screening western medicinal plants for estrogenic
compounds, researchers identified several flavone glycosides with
estrogenic activity in parsley (Petroselinum crispus).
They also found a new monoterpene glucoside, petroside. After
enhancing the estrogenic activity of the flavone glycosides by
removing their glycoside moieties, the researchers determined
that apigenin, diosmetin, and kaempferol had the most potent estrogenic
activity, which they deemed "nearly equal to those of the
isoflavones diadzein...and genistein..." In addition, according
to the investigators, seven days of oral treatment with methanolic
extract of parsley, apiin, and apigenin restored uterine weight
in ovarectomized mice. Yoshikawa M, Uemura T, Shimoda H, et
al. Medicinal foodstuffs XVIII. Phytoestrogens from the aerial
part of Petroselinum crispus Mill. (parsley) and structures of
6"-acetylapiin and a new monoterpene glycoside, petroside.
Chem Pharm Bull 2000; 48(7): 1039-1044.