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Anti-inflammatory activity of Padma 28
Padma 28, an herbal combination used in traditional Tibetan medicine
for anti-inflammatory and other effects, caused a significant
inhibition of inducible nitric oxide synthesis in tests utilizing
a mouse macrophage cell line. In humans, inducible nitric oxide
synthesis (iNOS) is associated with infectious and inflammatory
disease processes and is responsible for the vasodilation and
hypotension observed in cases of septic shock. The authors suggest
that inhibition of iNOS "might contribute to the anti-inflammatory
effects of Padma 28." Saussurea lappa and Terminalia
chebula, two of the herbal ingredients in Padma 28, inhibited
iNOS by decreasing iNOS protein and iNOS mRNA levels when assayed
separately. Moeslinger T, Friedl R, Volf I, et al. Inhibition
of inducible nitric oxide synthesis by the herbal preparation
Padma 28 in macrophage cell line. Can J Physiol Pharmacol
2000; 78: 861-866.
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