Herb
Research Foundation News Archive |
|
Ginkgo biloba
compares favorably to drug used in Alzheimer's treatment.
|
|
|
EGb-761, a standardized
extract of Ginkgo biloba, is approved by German authorities as
an effective treatment for primary degenerative dementia and vascular
dementia. Tacrine® (tetrahydroaminoacrine) is the only drug approved
in the U.S. for the treatment of Alzheimer's disease. An open, uncontrolled
trial was conducted to compare the pharmacological activity of ginkgo
and Tacrine in elderly patients with mild-to-moderate dementia. Results
showed that both substances exhibit "cognitive activator" type effects,
characterized by CEEG profiles demonstrating an increase of 7.5 to 13
cps activity and decreased slow frequencies. Ginkgo biloba (240 mg) exhibited
"cognitive activator" profiles in more subjects than Tacrine (40 mg),
and subjects who showed more cognitive-activator responses to the first
dose of ginkgo also demonstrated better therapeutic effects with chronic
administration of ginkgo. |
|
|
Itil T, Ahmed I, Le
Bars P, et al. "The pharmacological effects of ginkgo biloba (GB),
a plant extract, on the brain in comparison to Tacrine." Psychopharmacology
Bulletin 1996;32(3):459.
|
|
|
Back
to the HRF News Archive Table of Contents |