By: Robert S. McCaleb
Herb Research Foundation
1007 Pearl St., Suite 200
Boulder, CO 80302
BOTANICAL DESCRIPTION
Silybum marianum, a member of the Aster family (Asteraceae
or Compositae), is an annual or biennial which grows from 4
to 6 feet. Stems are glabrous, simple or little branched. Leaves
are to 2 1/2 feet long, 6-12 inches across, clasping, green
marbled or streaked with white veins; sharp-spined. Heads are
2-2 1/2 inches across, involucral bracts spreading to reflexed,
acuminate; achenes smooth, mottled with brown. Flowers are purple
tufts; receptacle densely bristle-spined. Plant flowers from
June through September. It grows mainly in Mediterranean region
where it is a wayside herb of uncultivated ground and waste
places. It is naturalized and a weed in the Eastern United States,
California and South America.
Morazzoni and Bombardelli describe the plant as follows: S.
marianum has a stem 20-150 cm high, rarely shorter, glabrous
or slightly downy, erect and branched in the upper part. The
leaves are alternate, large, white-veined, glabrous with strongly
spiny margin. The inflorescences are large and round capitula,
solitary at the apex of the stem or its branches, surrounded
by thorny bracts. The florets are hermaphrodite, tubular in
shape with corolla red-purple. The fruits are hard-skinned achenes
6 to 8 mm long, shiny, generally brownish in color with a white
silk-like pappus at the apex. The fruits are harvested in July-August
after blooming. (Morazzoni, 1995, pp.5-6)
OTHER NAMES
Silybum marianum: Carduus Marianus, Cnicus marianus, St. Mary's
Thistle, Marian Thistle, Milk Thistle, Holy Thistle ( not to
be confused with Blessed Thistle Cnicus benedictus).
USES
Part used: seeds, whole plant.
Young leaves (with spines removed) are eaten as a vegetable
in spring salads and as a spinach substitute. Young stalks,
peeled and soaked, are eaten like asparagus. The roots, soaked
in water overnight to remove bitterness, are eaten like salsify.
Milk Thistle's flower receptacle, resembling an artichoke, was
cooked and eaten like artichokes. (Foster, 1991)
Traditionally, tea made from whole plant used to improve appetite,
allay indigestion, restore liver function. Used for cirrhosis,
jaundice, hepatitis, liver poisoning from chemicals or drug
and alcohol abuse.
Silymarin, a seed extract, dramatically improves liver regeneration
in chronic viral hepatitis, cirrhosis, mushroom poisoning, and
other hepatopathies. German research suggests that silybin,
a flavonoid component of the seed, is clinically useful in treating
severe Amanita mushroom poisoning. Silymarin has demonstrated
significant activity against exposure to halogenated hydrocarbons.
While used clinically in Europe, its use in the U.S. is not
well known. Commercial preparations of the seed extracts are
manufactured in Europe. (Foster and Duke, 1990, p. 198; Morazzoni,
1995)
Adverse effects from ingesting any of the plant parts of Silybum
marianum are generally lacking from the literature. Animal experiments
have shown that seed extracts are safe, even in large doses,
with practically no side effects, as well as no embryo toxic
effect (Weiss, 1988).
The most recent clinical investigations have demonstrated that
the flavonolignan silibinin is the most effective compound.
Future breeding activities should be directed to the production
of genotypes and lines that produce silibinin. (Hetz et al,
1995)
In all references, it appears that this plant is used in particular
in the treatment of diseases of the liver.
ENVIRONMENT
Silybum marianum is native to the Mediterranean area.
It is grown and used medicinally in France, Italy, Germany,
Hungary, Greece and Poland. It is also present in Canary Islands,
Madeira and naturalized in the hot, dry areas of Central Europe,
North and South America, in Central and East Asia and Southern
Australia. It also grows wild in Egypt in the Nile Valley. It
is not generally found in Northern Italy, but it is frequent
in the central and southern regions and in the islands.
In Italy S. marianum is found on roadsides, waste places
and cultivated ground and it is distributed from the sea to
the submountain regions to 700-1100 m of altitude. It is cultivated
for ornament and naturalized or casual throughout a large part
of Europe. (Morazzoni, 1995)
California (USA) ranchers claim milk thistle loosens hard compacted
soil and make their own "clod-buster" from chopped
plants soaked in 55 gallon drums of water. (JL Hudson Seedsman)
PRODUCTION
It is difficult to find simple "how to grow" instructions for
Silybum marianum in English. There is major interest
in developing methods of cultivation which will yield the highest
silymarin content. Papers are listed which discuss different
water regimes and nitrogen fertilization levels in order to
obtain the highest silymarin content in the plant for its commercial
production for pharmaceutical use. (Hammouda, 1993)
The genus Silybum contains two species: S. marianum
(variegated white/green) and S. eburneum (completely
green). From crossing experiments it appears that the two species
are only variants. In European gardens Silybum has been cultivated
as a vegetable for centuries.
In the Nile Valley of Egypt Silybum marianum occurs
in two types, the most abundant has purple flowers while the
least abundant has white flowers. The seeds of the plant are
used for medicinal purposes.
Mean total mass of fruits, content and yield of silymarin were
determined for Silybum marianum Gaertn. as follows: 1.2
- 21.4 g/pot, 2.9 - 4.2% and 91-700 mg/pot, respectively. The
higher cropping of fruits as well as the content of silymarin
were obtained in the case of mineral fertilization with double
dose of phosphorus (NP2K), and those results were not the ground
moisture dependent. The best yield of silymarin from Silybum
marianum fruits (700 mg/pot) can be obtained on fertilization
with double dose of phosphorus and at 60% of moisture in the
ground. (Kozlowski, 1984)
In Egypt the plant was cultivated and subjected to different
agricultural conditions including the effect of water regime
70%, 60% and 45% per field capacity and nitrogen fertilization
levels 0, 50, 100, and 150 kg/feddan. The fruits grown under
the seven treatments were collected separately and subjected
to investigation in comparison with the two wild growing types
of S. marianum. (Hammouda, 1993). Cultivated Silybum marianum
yielded increased silymarin content when compared to wild Silybum.
Higher results were obtained with 60% water regime per field
capacity without fertilization. When soil was treated with different
nitrogen fertilization levels, the 100 and 150 kg nitrogen per
feddan gave the highest silymarin contents in the fruits (1.46%,
1.42% respectively) and relatively high contents in the ethyl
acetate extract (52.2% and 52.8% respectively). (Hammouda, 1993)
In areas with mild winters, the best seed is obtained by direct
seeding in midsummer and overwintering the rosettes. The following
spring, the already established plants bolt quickly to flower
and the seed has time to mature and darken during the summer.
In areas with hard winters, sow seed directly as an annual in
mid-spring. Sprouts in 1 to 3 weeks. (Horizon Herbs) Note: fresh
seed will not germinate at warm temperatures, only sprouting
at cool temperatures, but after 5 months of dry storage after
ripening, seeds will germinate will at warm temperatures. (JL
Hudson Seedsman)
Spines of plant are extremely sharp; rows should be spaced
at least 5 feet apart and thin plants to 2 feet apart in the
rows to allow for harvest of the capitulae -- which have more
spines at the tip of the bract. (Horizon Herbs)
REFERENCES
Bailey, Liberty Hyde and Ethel Zoe Bailey. (1976) Hortus
Third: A Concise Dictionary of Plants Cultivated in the United
States and Canada. Rev. and exp. by The Staff of the Liberty
Hyde Bailey Hortorium. New York. Macmillan Pub. Co.
Foster, Steven. (1991) Milk Thistle: Silybum marianum.
Botanical Series No. 305. Austin, TX: American Botanical Council.
Foster, Steven and James A. Duke. (1990) A Field Guide to
Medicinal Plants: Eastern and Central North America. Boston:
Houghton Mifflin Co.
Hammouda, F. M., S. I. Ismail, N. M. Hassan [et al]. (1993)
"Evaluation of the Silymarin Content in Silybum marianum
(L.) Gaertn. Cultivated under Different Agricultural Conditions."
Phytotherapy Research, 7(1):90-1.
Hetz, Erich, Reinhard Liersch and Otto Schieder. (1995) "Genetic
Investigations on Silybum marianum and S. eburneum
with respect to leaf colour, outcrossing ratio, and flavonolignan
composition." Planta Medica, 61: pp.54-57.
Horizon Herbs Seed Catalog (1996). Williams, Oregon USA
JL Hudson, Seedsman Catalog (1996). La Honda, California USA
Kozlowski, J. and M. Holynska. (1984) "Changes in content and
yield of Silymarin as well as the cropping of fruits of Silybum
marianum Gaertn. under influence of different fertilization
and moisture in a pot experiment." Herba Polonica, 30
(3-4):pp.191-198.
Morazzoni, Paolo and Ezio Bombardelli. (1995) "Silybum marianum
(Carduus marianus)." Fitoterapia, 46(1):pp.3-42.
Weiss, R. F. (1988) Herbal Medicine (tr. from German
by A.R. Meuss). Beaconsfield, England: Beaconsfield Publishers
Ltd.
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